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  Brain Disorders:

 

Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy ( MIM: 125310)

Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an autosomal dominant progressive disorder of the small arterial vessels of the brain caused by mutations in the NOTCH3 gene (  MIM: 600276 ). The disease manifests as migraine, strokes, and white matter lesions, with resultant cognitive impairment in some patients.